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KMID : 0869220220260010018
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Journal of Korean Geriatric Psychiatry
2022 Volume.26 No. 1 p.18 ~ p.22
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Choroid Plexus and Its Association of Subtypes of Delusion in Patient With Alzheimer’s Disease
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Son Sung-Mi
Lee Young-Min
Park Je-Min
Lee Byung-Dae
Moon Eun-Soo
Jeong Hee-Jeong
Suh Hwa-Gyu
Kim Kyung-Won
Kim Hak-Jin
Pak Kyoung-June
Choi Kyung-Un
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Abstract
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Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD).
Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics.
Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both choroid plexus were significantly reduced in AD+MD compared to AD+PD.
Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD. These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune responses in the choroid plexus.
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KEYWORD
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Choroid plexus, Alzheimer’s disease, Misidentification delusion
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